Wheezing is very much like the sound from a deflating balloon when you make it squeal by stretching the outlet. What exactly is happening when a sick patient wheezes as they exhale? That is a 180-degree thought reversal from interpreting them as only a “sign” of disease. We’ve seen evidence of this in our experiments. So wheezes and crackles actually “cause” disease. The cells respond with inflammation, which, itself, is a disease. They make the sound, and that mechanical event is also pounding away on the lung tissue. The physical mechanisms that cause wheezing and crackling, while smaller forces than a cough, are similar. Ouch!Īs an extreme example, the loudest sound a lung generates is a severe cough, which can cause, in rare instances, a pneumothorax (ruptured lung), i.e. If you clap hard enough, your hands will hurt. Well, for a sound to be created, a mechanical event must occur, like clapping your hands. You’ve found that that sounds could represent more than just the presence of a disease. Pulmonary edema is a common example, often a byproduct of heart failure.

Crackles, on the other hand, are only heard by a stethoscope and are a sign of too much fluid in the lung. Patients who wheeze can be so loud you can hear it standing next to them.

Typically wheezing is found in asthma and emphysema. These wheezes and crackles are “signs” of what diseases? There are normal sounds of air movement, but also there can be abnormal sounds, like wheezes during expiration (breathing out) and crackles during inspiration (breathing in). For the lungs, typically the patient is asked to breathe in and out deeply. Two important organs being monitored are the heart and the lungs. When doctors pull out a stethoscope, what are they listening for? And they represent a paradigm shift for how doctors understand what they hear through a stethoscope. The findings could eventually change how lung diseases are treated. Exploring this in humans is a research goal. His conclusion is based on evidence from experiments on microfluidic chips and on animal models. Grotberg, a professor of biomedical engineering and an MD, recently published a paper describing how the mechanics that produce those noises with every breath are likely a cause of injury and inflammation. Doctors know they’re the sounds of a problem in the lungs, but it turns out they might be more than symptoms-crackling and wheezing could also be the sounds of a disease progressing, according to a University of Michigan researcher.

Different lung sounds